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High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila

Genomic sequencing has implicated large numbers of genes and de novo mutations as potential disease risk factors. A high throughput in vivo model system is needed to validate gene associations with pathology. We developed a Drosophila-based functional system to screen candidate disease genes identif...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Zhu, Jun-yi, Fu, Yulong, Nettleton, Margaret, Richman, Adam, Han, Zhe
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300701/
https://ncbi.nlm.nih.gov/pubmed/28084990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22617
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