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Effect of Low Furanocoumarin Hybrid Grapefruit Juice Consumption on Midazolam Pharmacokinetics

The objectives of this study were to investigate the effect of grapefruit juice low in furanocoumarins on CYP3A activity and to summarize previous findings of enzyme inhibition measured by the metabolism of midazolam after intake of grapefruit juice. Twelve healthy volunteers participated in a prosp...

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Detalles Bibliográficos
Publicado en:J Clin Pharmacol
Main Authors: Kawaguchi-Suzuki, Marina, Nasiri-Kenari, Negar, Shuster, Jonathan, Gmitter, Fred, Cancalon, Paul, de Oliveria, Felipe, Kight, Jennifer, Handberg, Eileen, Pepine, Carl, Frye, Reginald F., Cooper-DeHoff, Rhonda M.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299073/
https://ncbi.nlm.nih.gov/pubmed/27503364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.807
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