Intestinal first pass metabolism of midazolam in liver cirrhosis – effect of grapefruit juice

AIMS: Grapefruit juice inhibits CYP3A4 in the intestinal wall leading to a reduced intestinal first pass metabolism and thereby an increased oral bioavailability of certain drugs. For example, it has been shown that the oral bioavailability of midazolam, a CYP3A4 substrate, increased by 52% in healt...

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Hlavní autoři: Andersen, Vibeke, Pedersen, Natalie, Larsen, Niels-Erik, Sonne, Jesper, Larsen, Steen
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2002
Témata:
Pharmacokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874412/
https://ncbi.nlm.nih.gov/pubmed/12207630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01615.x
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