A structural model for vinculin insertion into PIP(2)-containing membranes and the effect of insertion on vinculin activation and localization

Vinculin, a scaffolding protein that localizes to focal adhesions (FA) and adherens junctions, links the actin cytoskeleton to the adhesive super-structure. While vinculin binds to a number of cytoskeletal proteins, it can also associate with phosphatidylinositol 4,5-bisphosphate (PIP(2)) to drive m...

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Détails bibliographiques
Publié dans:Structure
Auteurs principaux: Thompson, Peter M., Ramachandran, Srinivas, Case, Lindsay B., Tolbert, Caitlin E., Tandon, Arpit, Pershad, Mihir, Dokholyan, Nikolay V., Waterman, Clare M., Campbell, Sharon L.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299030/
https://ncbi.nlm.nih.gov/pubmed/28089450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.12.002
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