Mitochondria-penetrating peptides conjugated to desferrioxamine as chelators for mitochondrial labile iron

Desferrioxamine (DFO) is a bacterial siderophore with a high affinity for iron, but low cell penetration. As part of our ongoing project focused on DFO-conjugates, we synthesized, purified, characterized and studied new mtDFOs (DFO conjugated to the Mitochondria Penetrating Peptides TAT(49-57), 1A,...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Alta, Roxana Y. P., Vitorino, Hector A., Goswami, Dibakar, Liria, Cleber W., Wisnovsky, Simon P., Kelley, Shana O., Machini, M. Terêsa, Espósito, Breno P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5298241/
https://ncbi.nlm.nih.gov/pubmed/28178347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171729
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