Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage

The highly reactive dicarbonyl methylglyoxal (MGO) is mainly formed as byproduct of glycolysis. Therefore, high blood glucose levels determine increased MGO accumulation. Nonetheless, MGO levels are also increased as consequence of the ineffective action of its main detoxification pathway, the glyox...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Nigro, Cecilia, Leone, Alessia, Raciti, Gregory Alexander, Longo, Michele, Mirra, Paola, Formisano, Pietro, Beguinot, Francesco, Miele, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297820/
https://ncbi.nlm.nih.gov/pubmed/28106778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18010188
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