Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage

The highly reactive dicarbonyl methylglyoxal (MGO) is mainly formed as byproduct of glycolysis. Therefore, high blood glucose levels determine increased MGO accumulation. Nonetheless, MGO levels are also increased as consequence of the ineffective action of its main detoxification pathway, the glyox...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Nigro, Cecilia, Leone, Alessia, Raciti, Gregory Alexander, Longo, Michele, Mirra, Paola, Formisano, Pietro, Beguinot, Francesco, Miele, Claudia
Format: Artigo
Language:Inglês
Published: MDPI 2017
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297820/
https://ncbi.nlm.nih.gov/pubmed/28106778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18010188
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