Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage

The highly reactive dicarbonyl methylglyoxal (MGO) is mainly formed as byproduct of glycolysis. Therefore, high blood glucose levels determine increased MGO accumulation. Nonetheless, MGO levels are also increased as consequence of the ineffective action of its main detoxification pathway, the glyox...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Nigro, Cecilia, Leone, Alessia, Raciti, Gregory Alexander, Longo, Michele, Mirra, Paola, Formisano, Pietro, Beguinot, Francesco, Miele, Claudia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2017
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Review
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297820/
https://ncbi.nlm.nih.gov/pubmed/28106778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18010188
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