miR-214-Dependent Increase of PHLPP2 Levels Mediates the Impairment of Insulin-Stimulated Akt Activation in Mouse Aortic Endothelial Cells Exposed to Methylglyoxal

Evidence has been provided linking microRNAs (miRNAs) and diabetic complications, by the regulation of molecular pathways, including insulin-signaling, involved in the pathophysiology of vascular dysfunction. Methylglyoxal (MGO) accumulates in diabetes and is associated with cardiovascular complicat...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Nigro, Cecilia, Mirra, Paola, Prevenzano, Immacolata, Leone, Alessia, Fiory, Francesca, Longo, Michele, Cabaro, Serena, Oriente, Francesco, Beguinot, Francesco, Miele, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855744/
https://ncbi.nlm.nih.gov/pubmed/29425121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19020522
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