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Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids

Single nucleotide variations (SNVs) can result in loss or gain of protein functional sites. We analyzed the effects of SNVs on enzyme active sites, ligand binding sites, and various types of post translational modification (PTM) sites. We found that, for most types of protein functional sites, the S...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Pan, Yang, Yan, Cheng, Hu, Yu, Fan, Yu, Pan, Qing, Wan, Quan, Torcivia-Rodriguez, John, Mazumder, Raja
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296879/
https://ncbi.nlm.nih.gov/pubmed/28176830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42169
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