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Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis

The ability to suppress host macrophage apoptosis is essential for M. tuberculosis (Mtb) to replicate intracellularly while protecting it from antibiotic treatment. We recently described that Mtb infection upregulated expression of the host phosphatase PPM1A, which impairs the antibacterial response...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Schaaf, Kaitlyn, Smith, Samuel R., Duverger, Alexandra, Wagner, Frederic, Wolschendorf, Frank, Westfall, Andrew O., Kutsch, Olaf, Sun, Jim
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296758/
https://ncbi.nlm.nih.gov/pubmed/28176854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42101
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