Loss of μ-opioid receptor signaling in nociceptors, and not spinal microglia, abrogates morphine tolerance without disrupting analgesic efficacy

Opioid pain medications cause detrimental side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). Tolerance and OIH counteract opioid analgesia, and drive dose escalation. The cell-types and receptors on which opioids act to initiate these maladaptive processes remain dispu...

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Udgivet i:Nat Med
Main Authors: Corder, Gregory, Tawfik, Vivianne L., Wang, Dong, Sypek, Elizabeth I., Low, Sarah A., Dickinson, Jasmine R., Sotoudeh, Chaudy, Clark, J. David, Barres, Ben A., Bohlen, Christopher J., Scherrer, Grégory
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296291/
https://ncbi.nlm.nih.gov/pubmed/28092666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4262
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