Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes

The human telomerase reverse transcriptase (hTERT) gene is repressed in most somatic cells, whereas the expression of the mouse mTert gene is widely detected. To understand the mechanisms of this human-specific repression, we constructed bacterial artificial chromosome (BAC) reporters using human an...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:FASEB J
Prif Awduron: Cheng, De, Zhao, Yuanjun, Wang, Shuwen, Zhang, Fan, Russo, Mariano, McMahon, Steven B., Zhu, Jiyue
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Federation of American Societies for Experimental Biology 2017
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295725/
https://ncbi.nlm.nih.gov/pubmed/27940549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601111R
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