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Structural basis for exploring the allosteric inhibition of human kidney type glutaminase
Cancer cells employ glutaminolysis to provide a source of intermediates for their upregulated biosynthetic needs. Glutaminase, which catalyzes the conversion of glutamine to glutamate, is gaining increasing attention as a potential drug target. Small-molecule inhibitors such as BPTES and CB-839, whi...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5295402/ https://ncbi.nlm.nih.gov/pubmed/27462863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10791 |
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