Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

Besides thriving on altered glucose metabolism, cancer cells undergo glutaminolysis to meet their energy demands. As the first enzyme in catalyzing glutaminolysis, human kidney-type glutaminase isoform (KGA) is becoming an attractive target for small molecules such as BPTES [bis-2-(5 phenylacetamido...

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Detalhes bibliográficos
Main Authors: Thangavelu, K., Pan, Catherine Qiurong, Karlberg, Tobias, Balaji, Ganapathy, Uttamchandani, Mahesh, Suresh, Valiyaveettil, Schüler, Herwig, Low, Boon Chuan, Sivaraman, J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356676/
https://ncbi.nlm.nih.gov/pubmed/22538822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116573109
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