Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells

Glycolytic enzymes are known to play pivotal roles in cancer cell survival, yet their molecular mechanisms remain poorly understood. Phosphoglycerate mutase 1 (PGAM1) is an important glycolytic enzyme that coordinates glycolysis, pentose phosphate pathway, and serine biosynthesis in cancer cells. He...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Qu, Jia, Sun, Wenyi, Zhong, Jie, Lv, Hao, Zhu, Mingrui, Xu, Jun, Jin, Nan, Xie, Zuoquan, Tan, Minjia, Lin, Shu-Hai, Geng, Meiyu, Ding, Jian, Huang, Min
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294784/
https://ncbi.nlm.nih.gov/pubmed/28122957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201607008
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