Antitumour activity of trabectedin in myelodysplastic/myeloproliferative neoplasms

BACKGROUND: Juvenile myelomonocytic leukaemia (JMML) and chronic myelomonocytic leukaemia (CMML) are myelodysplastic myeloproliferative (MDS/MPN) neoplasms with unfavourable prognosis and without effective chemotherapy treatment. Trabectedin is a DNA minor groove binder acting as a modulator of tran...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Romano, Michela, Della Porta, Matteo Giovanni, Gallì, Anna, Panini, Nicolò, Licandro, Simonetta Andrea, Bello, Ezia, Craparotta, Ilaria, Rosti, Vittorio, Bonetti, Elisa, Tancredi, Richard, Rossi, Marianna, Mannarino, Laura, Marchini, Sergio, Porcu, Luca, Galmarini, Carlos M, Zambelli, Alberto, Zecca, Marco, Locatelli, Franco, Cazzola, Mario, Biondi, Andrea, Rambaldi, Alessandro, Allavena, Paola, Erba, Eugenio, D'Incalci, Maurizio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294481/
https://ncbi.nlm.nih.gov/pubmed/28072764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.424
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