Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin

BACKGROUND: In order to investigate the mechanisms of acquired resistance to trabectedin, trabectedin-resistant human myxoid liposarcoma (402-91/T) and ovarian carcinoma (A2780/T) cell lines were derived and characterised in vitro and in vivo. METHODS: Resistant cell lines were obtained by repeated...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Colmegna, B, Uboldi, S, Frapolli, R, Licandro, S A, Panini, N, Galmarini, C M, Badri, Nadia, Spanswick, V J, Bingham, J P, Kiakos, Konstantinos, Erba, E, Hartley, J A, D'Incalci, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701998/
https://ncbi.nlm.nih.gov/pubmed/26633559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.407
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