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Evolution of new nonantibody proteins via iterative somatic hypermutation
B lymphocytes use somatic hypermutation (SHM) to optimize immunoglobulins. Although SHM can rescue single point mutations deliberately introduced into nonimmunoglobulin genes, such experiments do not show whether SHM can efficiently evolve challenging novel phenotypes requiring multiple unforeseeabl...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC529417/ https://ncbi.nlm.nih.gov/pubmed/15556995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407752101 |
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