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Allostery and Hysteresis are coupled in human UDP-glucose dehydrogenase
Human UDP-glucose dehydrogenase (hUGDH) is regulated by an atypical allosteric mechanism in which the feedback inhibitor UDP-xylose (UDP-Xyl) competes with substrate for the active site. Binding of UDP-Xyl triggers the T131-Loop/α6 allosteric switch, which converts the hexameric structure of hUGDH i...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5293408/ https://ncbi.nlm.nih.gov/pubmed/27966912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01044 |
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