A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice

Monospermic fertilization is mediated by the extracellular zona pellucida composed of ZP1, ZP2 and ZP3. Sperm bind to the N-terminus of ZP2 which is cleaved after fertilization by ovastacin (encoded by Astl) exocytosed from egg cortical granules to prevent sperm binding. Astl(Null) mice lack the pos...

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Vydáno v:PLoS Genet
Hlavní autoři: Xiong, Bo, Zhao, Yangu, Beall, Stephanie, Sadusky, Anna Burkart, Dean, Jurrien
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293279/
https://ncbi.nlm.nih.gov/pubmed/28114310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006580
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