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Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy

The PI3K pathway is hyperactivated in most cancers, yet the capacity of PI3K inhibitors to induce tumor cell death is limited. The efficacy of PI3K inhibition can also derive from interference with the cancer cells’ ability to respond to stromal signals, as illustrated by the approved PI3Kδ inhibito...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Okkenhaug, Klaus, Graupera, Mariona, Vanhaesebroeck, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293166/
https://ncbi.nlm.nih.gov/pubmed/27655435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0716
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