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Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism
Cholesterol is important for normal brain function. The brain synthesizes its own cholesterol, presumably in astrocytes. We have previously shown that diabetes results in decreased brain cholesterol synthesis by a reduction in sterol regulatory element-binding protein 2 (SREBP2)-regulated transcript...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5293102/ https://ncbi.nlm.nih.gov/pubmed/28096339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620506114 |
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