Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4

With-no-lysine kinase 4 (WNK4) regulates electrolyte homeostasis and blood pressure. WNK4 phosphorylates the kinases SPAK (Ste20-related proline alanine-rich kinase) and OSR1 (oxidative stress responsive kinase), which then phosphorylate and activate the renal Na-Cl cotransporter (NCC). WNK4 levels...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Castañeda-Bueno, Maria, Arroyo, Juan Pablo, Zhang, Junhui, Puthumana, Jeremy, Yarborough, Orlando, Shibata, Shigeru, Rojas-Vega, Lorena, Gamba, Gerardo, Rinehart, Jesse, Lifton, Richard P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293014/
https://ncbi.nlm.nih.gov/pubmed/28096417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620315114
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