Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells

Mice deficient in the transcriptional repressor B-cell CLL/lymphoma 6 (Bcl6) exhibit similar T helper 2 (T(H)2) immune responses as patients with allergic diseases. However, the molecular mechanisms underlying Bcl6-directed regulation of T(H)2 cytokine genes remain unclear. We identified multiple Bc...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Ogasawara, Takashi, Hatano, Masahiko, Satake, Hisae, Ikari, Jun, Taniguchi, Toshibumi, Tsuruoka, Nobuhide, Watanabe-Takano, Haruko, Fujimura, Lisa, Sakamoto, Akemi, Hirata, Hirokuni, Sugiyama, Kumiya, Fukushima, Yasutsugu, Nakae, Susumu, Matsumoto, Kenji, Saito, Hirohisa, Fukuda, Takeshi, Kurasawa, Kazuhiro, Tatsumi, Koichiro, Tokuhisa, Takeshi, Arima, Masafumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293011/
https://ncbi.nlm.nih.gov/pubmed/28096407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613528114
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