ADAR1 Protein Induces Adenosine-targeted DNA Mutations in Senescent Bcl6 Gene-deficient Cells

Somatic mutations accumulate in senescent cells. Bcl6, which functions as a transcriptional repressor, has been identified as a potent inhibitor of cell senescence, but a role of Bcl6 in the accumulation of somatic mutations has remained unclear. Ig class-switch recombination simultaneously induces...

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Main Authors: Tsuruoka, Nobuhide, Arima, Masafumi, Yoshida, Nobuya, Okada, Seiji, Sakamoto, Akemi, Hatano, Masahiko, Satake, Hisae, Arguni, Eggi, Wang, Ji-Yang, Yang, Jing-Hua, Nishikura, Kazuko, Sekiya, Souei, Shozu, Makio, Tokuhisa, Takeshi
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2013
נושאים:
Immunology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543032/
https://ncbi.nlm.nih.gov/pubmed/23209284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.365718
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