Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells

BACKGROUND: The molecular and cellular pathways driving the pathogenesis of severe asthma are poorly defined. Tumor progression locus 2 (TPL-2) (COT, MAP3K8) kinase activates the MEK1/2-extracellular-signal regulated kinase 1/2 MAP kinase signaling pathway following Toll-like receptor, TNFR1, and IL...

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Bibliografiske detaljer
Udgivet i:J Allergy Clin Immunol
Main Authors: Kannan, Yashaswini, Li, Yanda, Coomes, Stephanie M., Okoye, Isobel S., Pelly, Victoria S., Sriskantharajah, Srividya, Gückel, Eva, Webb, Lauren, Czieso, Stephanie, Nikolov, Nikolay, MacDonald, Andrew S., Ley, Steven C., Wilson, Mark S.
Format: Artigo
Sprog:Inglês
Udgivet: Mosby 2017
Fag:
Mechanisms of Allergy and Clinical Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292997/
https://ncbi.nlm.nih.gov/pubmed/27484038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.05.031
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