Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency

CONTEXT AND AIMS: Functional leptin deficiency is characterized by high levels of circulating immunoreactive leptin (irLep), but a reduced bioactivity of the hormone due to defective receptor binding. As a result of the fact that affected patients can be successfully treated with metreleptin, it was...

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Dettagli Bibliografici
Pubblicato in:Eur J Endocrinol
Autori principali: Wabitsch, Martin, Pridzun, Lutz, Ranke, Michael, von Schnurbein, Julia, Moss, Anja, Brandt, Stephanie, Kohlsdorf, Katja, Moepps, Barbara, Schaab, Michael, Funcke, Jan-Bernd, Gierschik, Peter, Fischer-Posovszky, Pamela, Flehmig, Bertram, Kratzsch, Jürgen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Bioscientifica Ltd 2016
Soggetti:
Clinical Study
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292973/
https://ncbi.nlm.nih.gov/pubmed/28007844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EJE-16-0821
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