TYK2 is a key regulator of the surveillance of B lymphoid tumors

Aberrant activation of the JAK-STAT pathway has been implicated in tumor formation; for example, constitutive activation of JAK2 kinase or the enforced expression of STAT5 induces leukemia in mice. We show here that the Janus kinase TYK2 serves an opposite function. Mice deficient in TYK2 developed...

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Main Authors: Stoiber, Dagmar, Kovacic, Boris, Schuster, Christian, Schellack, Carola, Karaghiosoff, Marina, Kreibich, Rita, Weisz, Eva, Artwohl, Michaela, Kleine, Olaf C., Muller, Mathias, Baumgartner-Parzer, Sabina, Ghysdael, Jacques, Freissmuth, Michael, Sexl, Veronika
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC529282/
https://ncbi.nlm.nih.gov/pubmed/15578097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422315
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