TYK2 is a key regulator of the surveillance of B lymphoid tumors

Aberrant activation of the JAK-STAT pathway has been implicated in tumor formation; for example, constitutive activation of JAK2 kinase or the enforced expression of STAT5 induces leukemia in mice. We show here that the Janus kinase TYK2 serves an opposite function. Mice deficient in TYK2 developed...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Stoiber, Dagmar, Kovacic, Boris, Schuster, Christian, Schellack, Carola, Karaghiosoff, Marina, Kreibich, Rita, Weisz, Eva, Artwohl, Michaela, Kleine, Olaf C., Muller, Mathias, Baumgartner-Parzer, Sabina, Ghysdael, Jacques, Freissmuth, Michael, Sexl, Veronika
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Clinical Investigation 2004
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC529282/
https://ncbi.nlm.nih.gov/pubmed/15578097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422315
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