Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ

PPARα, β/δ, and γ regulate genes involved in the control of lipid metabolism and inflammation and are expressed in all major cell types of atherosclerotic lesions. In vitro studies have suggested that PPARs exert antiatherogenic effects by inhibiting the expression of proinflammatory genes and enhan...

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Detalhes bibliográficos
Main Authors: Li, Andrew C., Binder, Christoph J., Gutierrez, Alejandra, Brown, Kathleen K., Plotkin, Christine R., Pattison, Jennifer W., Valledor, Annabel F., Davis, Roger A., Willson, Timothy M., Witztum, Joseph L., Palinski, Wulf, Glass, Christopher K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529277/
https://ncbi.nlm.nih.gov/pubmed/15578089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200418730
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