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Metabolism of the Anti-Hepatitis C Virus Nucleoside β-d-N(4)-Hydroxycytidine in Different Liver Cells
β-d-N(4)-Hydroxycytidine (NHC) was found to have selective anti-hepatitis C virus (HCV) activity in the HCV replicon system (clone A). The intracellular metabolism of tritiated NHC was investigated in the HCV replicon system, Huh-7 cells, HepG2 cells, and primary human hepatocytes. Incubation of cel...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC529212/ https://ncbi.nlm.nih.gov/pubmed/15561837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4636-4642.2004 |
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