Metabolism of the Anti-Hepatitis C Virus Nucleoside β-d-N(4)-Hydroxycytidine in Different Liver Cells

β-d-N(4)-Hydroxycytidine (NHC) was found to have selective anti-hepatitis C virus (HCV) activity in the HCV replicon system (clone A). The intracellular metabolism of tritiated NHC was investigated in the HCV replicon system, Huh-7 cells, HepG2 cells, and primary human hepatocytes. Incubation of cel...

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Detalhes bibliográficos
Main Authors: Hernandez-Santiago, Brenda I., Beltran, Thierry, Stuyver, Lieven, Chu, Chung K., Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529212/
https://ncbi.nlm.nih.gov/pubmed/15561837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4636-4642.2004
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