Functional Cloning of Bacillus anthracis Dihydrofolate Reductase and Confirmation of Natural Resistance to Trimethoprim

Bacillus anthracis is reported to be naturally resistant to trimethoprim (TMP), a drug that inhibits dihydrofolate reductase (DHFR), a key enzyme in the folate pathway. A microdilution broth assay established that the MIC of TMP for B. anthracis Sterne is >2,048 but ≤4,096 μg/ml. A putative DHFR...

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Hlavní autoři: Barrow, Esther W., Bourne, Philip C., Barrow, William W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC529193/
https://ncbi.nlm.nih.gov/pubmed/15561838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4643-4649.2004
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