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In Vitro Efficacy of New Antifolates against Trimethoprim-Resistant Bacillus anthracis
Bacillus anthracis is innately resistant to trimethoprim (TMP), a synthetic antifolate that selectively inhibits several bacterial dihydrofolate reductases (DHFRs) but not human DHFR. Previously, we were able to confirm that TMP resistance in B. anthracis (MIC > 2,048 μg/ml) is due to the lack of...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology (ASM)
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2167980/ https://ncbi.nlm.nih.gov/pubmed/17875993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00628-07 |
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