In Vitro Efficacy of New Antifolates against Trimethoprim-Resistant Bacillus anthracis

Bacillus anthracis is innately resistant to trimethoprim (TMP), a synthetic antifolate that selectively inhibits several bacterial dihydrofolate reductases (DHFRs) but not human DHFR. Previously, we were able to confirm that TMP resistance in B. anthracis (MIC > 2,048 μg/ml) is due to the lack of...

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Bibliografiske detaljer
Main Authors: Barrow, Esther W., Dreier, Jürg, Reinelt, Stefan, Bourne, Philip C., Barrow, William W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2007
Fag:
Susceptibility
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2167980/
https://ncbi.nlm.nih.gov/pubmed/17875993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00628-07
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