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Control of B Cell Production by the Adaptor Protein Lnk: Definition of a Conserved Family of Signal-Modulating Proteins
Lnk is an SH2 domain–containing adaptor protein expressed preferentially in lymphocytes. To illuminate the importance of Lnk, we generated lnk(−/−) mice. Whereas T cell development was unaffected, pre-B and immature B cells accumulated in the spleens. In the bone marrow, B-lineage cells were proport...
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| Udgivet i: | Immunity |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5291696/ https://ncbi.nlm.nih.gov/pubmed/11114373 |
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