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Design of Trypanosoma rangeli sialidase mutants with improved trans-sialidase activity
A sialidase (EC 3.2.1.18) from the non-pathogenic Trypanosoma rangeli, TrSA, has been shown to exert trans-sialidase activity after mutation of five specific amino acids in the active site (M96V, A98P, S120Y, G249Y, Q284P) to form the so-called TrSA(5mut) enzyme. By computational and hypothesis driv...
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| Udgivet i: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5291517/ https://ncbi.nlm.nih.gov/pubmed/28158299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171585 |
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