Inefficiencies and Patient Burdens in the Development of the Targeted Cancer Drug Sorafenib: A Systematic Review

Failure in cancer drug development exacts heavy burdens on patients and research systems. To investigate inefficiencies and burdens in targeted drug development in cancer, we conducted a systematic review of all prelicensure trials for the anticancer drug, sorafenib (Bayer/Onyx Pharmaceuticals). We...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Mattina, James, Carlisle, Benjamin, Hachem, Yasmina, Fergusson, Dean, Kimmelman, Jonathan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Meta-Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291369/
https://ncbi.nlm.nih.gov/pubmed/28158308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2000487
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