The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity

Microtubule-targeting agents (MTAs) are widely used anticancer agents, but toxicities such as neuropathy limit their clinical use. MTAs bind to and alter the stability of microtubules, causing cell death in mitosis. We describe DZ-2384, a preclinical compound that exhibits potent antitumor activity...

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Publicat a:Sci Transl Med
Autors principals: Wieczorek, Michal, Tcherkezian, Joseph, Bernier, Cynthia, Prota, Andrea E., Chaaban, Sami, Rolland, Yannève, Godbout, Claude, Hancock, Mark A., Arezzo, Joseph C., Ocal, Ozhan, Rocha, Cecilia, Olieric, Natacha, Hall, Anita, Ding, Hui, Bramoullé, Alexandre, Annis, Matthew G., Zogopoulos, George, Harran, Patrick G., Wilkie, Thomas M., Brekken, Rolf A., Siegel, Peter M., Steinmetz, Michel O., Shore, Gordon C., Brouhard, Gary J., Roulston, Anne
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291303/
https://ncbi.nlm.nih.gov/pubmed/27856798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag1093
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