Editor’s Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure–Activity Relationships and Receptor Modeling

1,4-Dihydroxy-2-naphthoic acid (1,4-DHNA) is a bacterial-derived metabolite that binds the aryl hydrocarbon receptor (AhR) and exhibits anti-inflammatory activity in the gut. The structure-dependent AhR activity of hydroxyl/carboxy-substituted naphthoic acids (NAs) was determined in young adult mous...

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Enregistré dans:
Détails bibliographiques
Publié dans:Toxicol Sci
Auteurs principaux: Cheng, Yating, Jin, Un-Ho, Davidson, Laurie A., Chapkin, Robert S., Jayaraman, Arul, Tamamis, Phanourios, Orr, Asuka, Allred, Clint, Denison, Michael S., Soshilov, Anatoly, Weaver, Evelyn, Safe, Stephen
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
Microbial-Derived Aryl Hydrocarbon Receptor Ligands
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291215/
https://ncbi.nlm.nih.gov/pubmed/27837168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw230
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