Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects

Hydroxylated chalcones are phytochemicals which are biosynthetic precursors of flavonoids and their 1,3-diaryl-prop-2-en-1-one structure is used as a scaffold for drug development. In this study, the structure-dependent activation of aryl hydrocarbon receptor (AhR)-responsive CYP1A1, CYP1B1, and UGT...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Park, Hyejin, Jin, Un-Ho, Karki, Keshav, Allred, Clinton, Davidson, Laurie A, Chapkin, Robert S, Orr, Asuka A, Nowshad, Farrhin, Jayaraman, Arul, Tamamis, Phanourios, Safe, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Molecular, Biochemical, and Systems Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7916741/
https://ncbi.nlm.nih.gov/pubmed/33263770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa179
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