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Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes

The tryptophan microbiota metabolites indole-3-acetate, indole-3-aldehyde, indole, and tryptamine are aryl hydrocarbon receptor (AhR) ligands, and in this study we investigated their AhR agonist and antagonist activities in nontransformed young adult mouse colonocyte (YAMC) cells. Using Cyp1a1 mRNA...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Cheng, Yating, Jin, Un-Ho, Allred, Clint D., Jayaraman, Arul, Chapkin, Robert S., Safe, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576676/
https://ncbi.nlm.nih.gov/pubmed/25873348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.063677
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