Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes

The tryptophan microbiota metabolites indole-3-acetate, indole-3-aldehyde, indole, and tryptamine are aryl hydrocarbon receptor (AhR) ligands, and in this study we investigated their AhR agonist and antagonist activities in nontransformed young adult mouse colonocyte (YAMC) cells. Using Cyp1a1 mRNA...

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Bibliografiske detaljer
Udgivet i:Drug Metab Dispos
Main Authors: Cheng, Yating, Jin, Un-Ho, Allred, Clint D., Jayaraman, Arul, Chapkin, Robert S., Safe, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
Fag:
Special Section on Drug Metabolism and the Microbiome
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576676/
https://ncbi.nlm.nih.gov/pubmed/25873348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.063677
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