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Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes

The tryptophan microbiota metabolites indole-3-acetate, indole-3-aldehyde, indole, and tryptamine are aryl hydrocarbon receptor (AhR) ligands, and in this study we investigated their AhR agonist and antagonist activities in nontransformed young adult mouse colonocyte (YAMC) cells. Using Cyp1a1 mRNA...

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Bibliografische gegevens
Gepubliceerd in:Drug Metab Dispos
Hoofdauteurs: Cheng, Yating, Jin, Un-Ho, Allred, Clint D., Jayaraman, Arul, Chapkin, Robert S., Safe, Stephen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2015
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576676/
https://ncbi.nlm.nih.gov/pubmed/25873348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.063677
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