Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1) is a single chain oxidoreductase that catalyzes tryptophan degradation to kynurenine. In cancer, it exerts an immunosuppressive function as part of an acquired mechanism of immune escape. Recently, we demonstrated that IDO1 expression is significantly higher in a...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Moretti, Sonia, Menicali, Elisa, Nucci, Nicole, Voce, Pasquale, Colella, Renato, Melillo, Rosa Marina, Liotti, Federica, Morelli, Silvia, Fallarino, Francesca, Macchiarulo, Antonio, Santoro, Massimo, Avenia, Nicola, Puxeddu, Efisio
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2017
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290952/
https://ncbi.nlm.nih.gov/pubmed/27994058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745448
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