Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1) is a single chain oxidoreductase that catalyzes tryptophan degradation to kynurenine. In cancer, it exerts an immunosuppressive function as part of an acquired mechanism of immune escape. Recently, we demonstrated that IDO1 expression is significantly higher in a...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Moretti, Sonia, Menicali, Elisa, Nucci, Nicole, Voce, Pasquale, Colella, Renato, Melillo, Rosa Marina, Liotti, Federica, Morelli, Silvia, Fallarino, Francesca, Macchiarulo, Antonio, Santoro, Massimo, Avenia, Nicola, Puxeddu, Efisio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290952/
https://ncbi.nlm.nih.gov/pubmed/27994058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745448
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