Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV

Mutations in TRPML1 cause the lysosomal storage disease mucolipidosis type IV (MLIV). The role of TRPML1 in cell function and how the mutations cause the disease are not well understood. Most studies focus on the role of TRPML1 in constitutive membrane trafficking to and from the lysosomes. However,...

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Publicado no:EMBO Rep
Main Authors: Park, Soonhong, Ahuja, Malini, Kim, Min Seuk, Brailoiu, G Cristina, Jha, Archana, Zeng, Mei, Baydyuk, Maryna, Wu, Ling‐Gang, Wassif, Christopher A, Porter, Forbes D, Zerfas, Patricia M, Eckhaus, Michael A, Brailoiu, Eugen, Shin, Dong Min, Muallem, Shmuel
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290820/
https://ncbi.nlm.nih.gov/pubmed/26682800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541542
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