Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV

Mutations in TRPML1 cause the lysosomal storage disease mucolipidosis type IV (MLIV). The role of TRPML1 in cell function and how the mutations cause the disease are not well understood. Most studies focus on the role of TRPML1 in constitutive membrane trafficking to and from the lysosomes. However,...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:EMBO Rep
Päätekijät: Park, Soonhong, Ahuja, Malini, Kim, Min Seuk, Brailoiu, G Cristina, Jha, Archana, Zeng, Mei, Baydyuk, Maryna, Wu, Ling‐Gang, Wassif, Christopher A, Porter, Forbes D, Zerfas, Patricia M, Eckhaus, Michael A, Brailoiu, Eugen, Shin, Dong Min, Muallem, Shmuel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2015
Aiheet:
Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290820/
https://ncbi.nlm.nih.gov/pubmed/26682800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541542
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