Binding to Nonmethylated CpG DNA Is Essential for Target Recognition, Transactivation, and Myeloid Transformation by an MLL Oncoprotein

The MLL gene is a frequent target for leukemia-associated chromosomal translocations that generate dominant-acting chimeric oncoproteins. These invariably contain the amino-terminal 1,400 residues of MLL fused with one of a variety of over 30 distinct nuclear or cytoplasmic partner proteins. Despite...

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Hlavní autoři: Ayton, Paul M., Chen, Everett H., Cleary, Michael L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC529055/
https://ncbi.nlm.nih.gov/pubmed/15542854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.23.10470-10478.2004
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