Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression

MLL (for mixed-lineage leukemia) is a proto-oncogene that is mutated in a variety of human leukemias. Its product, a homolog of Drosophila melanogaster trithorax, displays intrinsic histone methyltransferase activity and functions genetically to maintain embryonic Hox gene expression. Here we report...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Yokoyama, Akihiko, Wang, Zhong, Wysocka, Joanna, Sanyal, Mrinmoy, Aufiero, Deborah J., Kitabayashi, Issay, Herr, Winship, Cleary, Michael L.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 2004
Assuntos:	Transcriptional Regulation
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC480881/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15199122/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.13.5639-5649.2004
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