Deficiency in SNM1 Abolishes an Early Mitotic Checkpoint Induced by Spindle Stress

Spindle poisons represent an important class of anticancer drugs that act by interfering with microtubule polymerization and dynamics and thereby induce mitotic checkpoints and apoptosis. Here we show that mammalian SNM1 functions in an early mitotic stress checkpoint that is distinct from the well-...

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Autores principales: Akhter, Shamima, Richie, Christopher T., Deng, Jian Min, Brey, Eric, Zhang, Xiaoshan, Patrick, Charles, Behringer, Richard R., Legerski, Randy J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
DNA Dynamics and Chromosome Structure
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC529044/
https://ncbi.nlm.nih.gov/pubmed/15542852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.23.10448-10455.2004
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