Deficiency in SNM1 Abolishes an Early Mitotic Checkpoint Induced by Spindle Stress

Spindle poisons represent an important class of anticancer drugs that act by interfering with microtubule polymerization and dynamics and thereby induce mitotic checkpoints and apoptosis. Here we show that mammalian SNM1 functions in an early mitotic stress checkpoint that is distinct from the well-...

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Bibliografski detalji
Glavni autori: Akhter, Shamima, Richie, Christopher T., Deng, Jian Min, Brey, Eric, Zhang, Xiaoshan, Patrick, Charles, Behringer, Richard R., Legerski, Randy J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
DNA Dynamics and Chromosome Structure
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC529044/
https://ncbi.nlm.nih.gov/pubmed/15542852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.23.10448-10455.2004
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