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Deficiency in SNM1 Abolishes an Early Mitotic Checkpoint Induced by Spindle Stress
Spindle poisons represent an important class of anticancer drugs that act by interfering with microtubule polymerization and dynamics and thereby induce mitotic checkpoints and apoptosis. Here we show that mammalian SNM1 functions in an early mitotic stress checkpoint that is distinct from the well-...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC529044/ https://ncbi.nlm.nih.gov/pubmed/15542852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.23.10448-10455.2004 |
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