Deficiency in SNM1 Abolishes an Early Mitotic Checkpoint Induced by Spindle Stress

Spindle poisons represent an important class of anticancer drugs that act by interfering with microtubule polymerization and dynamics and thereby induce mitotic checkpoints and apoptosis. Here we show that mammalian SNM1 functions in an early mitotic stress checkpoint that is distinct from the well-...

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Detalhes bibliográficos
Main Authors: Akhter, Shamima, Richie, Christopher T., Deng, Jian Min, Brey, Eric, Zhang, Xiaoshan, Patrick, Charles, Behringer, Richard R., Legerski, Randy J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529044/
https://ncbi.nlm.nih.gov/pubmed/15542852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.23.10448-10455.2004
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