A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is autophagy, where damaged organelles are marked for disposal via ubiquitylation by Parkin. Here we report a novel pathway for mitochondrial eli...

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Publicado no:Nat Commun
Main Authors: Hammerling, Babette C., Najor, Rita H., Cortez, Melissa Q., Shires, Sarah E., Leon, Leonardo J., Gonzalez, Eileen R., Boassa, Daniela, Phan, Sébastien, Thor, Andrea, Jimenez, Rebecca E., Li, Hong, Kitsis, Richard N., Dorn II, Gerald W., Sadoshima, Junichi, Ellisman, Mark H., Gustafsson, Åsa B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290275/
https://ncbi.nlm.nih.gov/pubmed/28134239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14050
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