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Beyond Mitophagy: The Diversity and Complexity of Parkin Function

Parkin is an E3 ubiquitin ligase that mediates mitochondrial autophagy, or mitophagy, in multiple cell types. While discovered in the context of Parkinson’s disease, Parkin is also an important regulator of mitophagy in the heart. In addition, while most current work is focused on the role of Parkin...

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Bibliographic Details
Published in:Circ Res
Main Authors: Shires, Sarah E., Kitsis, Richard N., Gustafsson, Åsa B.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407365/
https://ncbi.nlm.nih.gov/pubmed/28408450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.310179
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