THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

Peripheral T-cell lymphomas (PTCL) are aggressive diseases with poor response to chemotherapy and dismal survival. Identification of effective strategies to target PTCL biology represents an urgent need. Here we report that PTCL are sensitive to transcription-targeting drugs, and, in particular, to...

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Publicado no:Nat Commun
Main Authors: Cayrol, Florencia, Praditsuktavorn, Pannee, Fernando, Tharu M., Kwiatkowski, Nicholas, Marullo, Rosella, Calvo-Vidal, M. Nieves, Phillip, Jude, Pera, Benet, Yang, Shao Ning, Takpradit, Kaipol, Roman, Lidia, Gaudiano, Marcello, Crescenzo, Ramona, Ruan, Jia, Inghirami, Giorgio, Zhang, Tinghu, Cremaschi, Graciela, Gray, Nathanael S., Cerchietti, Leandro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290269/
https://ncbi.nlm.nih.gov/pubmed/28134252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14290
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